Technical Data

043491
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000541.1
Gene ID
7306
Gene #
TYRP1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TYRP1, ID (TYRP1, CAS2, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic acid oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1)
TYRP1, CAS2, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic acid oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.

The tyrosinase family in vertebrates consists of three related melanogenic enzymes: tryrosinase, tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2). These proteins control melanin production in pigment cells and play a crucial role in determining vertebrate coloration and are expressed by melanoma cells, normal melanocytes and nevi, but not carcinomas or sarcomas.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TYRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-371 amino acids from the Central region of human TYRP1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Rausch, M.P., et al. J. Immunol. 185(5):2828-2835(2010)|Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :|Edwards, M., et al. PLoS Genet. 6 (3), E1000867 (2010) :|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
USBio References
No references available
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