Technical Data

043532
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_060281.2
Gene ID
54926
Gene #
UBE2R2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-UBE2R2, ID (UBE2R2, CDC34B, UBC3B, Ubiquitin-conjugating enzyme E2 R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2)
UBE2R2, CDC34B, UBC3B, Ubiquitin-conjugating enzyme E2 R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
UBE2R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-169 amino acids from the Central region of human UBE2R2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)|Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)|Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)|Humphray, S.J., et al. Nature 429(6990):369-374(2004)
USBio References
No references available
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