043592
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_079493.1Gene ID
80328Gene #
ULBP2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-ULBP2, ID (ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2)
ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 88-116 in the central region of human ULBP2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human ULBP2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010) 2. Nuckel, H., et al. Leukemia 24(6):1152-1159(2010) 3. Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010) 4. Davila, S., et al. Genes Immun. 11(3):232-238(2010) 5. Ward, J., et al. PLoS Pathog. 5 (10), E1000613 (2009) :USBio References
No references available