Technical Data

043850
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_005819.3
Gene ID
10238
Gene #
DCAF7
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-WDR68, CT (DCAF7, HAN11, WDR68, DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog)
DCAF7, HAN11, WDR68, DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog

WDR68 is involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
WDR68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human WDR68.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Ritterhoff, S., et al. EMBO J. 29(22):3750-3761(2010)|Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)|Morita, K., et al. J. Dermatol. Sci. 44(1):11-20(2006)|Jin, J., et al. Mol. Cell 23(5):709-721(2006)|Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
USBio References
No references available
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