WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, WHSC1-like protein 1, Wolf-Hirschhorn syndrome candidate 1-like protein 1, Whistle, NSD3, DC28)

043874

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Isotype

IgG

Grade

Affinity Purified

Applications

E WB

Crossreactivity

Hu Mo

Gene ID

54904

Gene #

WHSC1L1

Shipping Temp

Blue Ice

Storage Temp

-20°C

Rabbit Anti-WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, WHSC1-like protein 1, Wolf-Hirschhorn syndrome candidate 1-like protein 1, Whistle, NSD3, DC28)

Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, WHSC1-like protein 1, Wolf-Hirschhorn syndrome candidate 1-like protein 1, Whistle, NSD3, DC28

WHSC1L1 is a histone methyltransferase. This protein preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia.

Applications

Suitable for use in Western Blot, ELISA

Recommended Dilution

ELISA: 1:1,000 Western Blot: 1:100-500

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

WHSC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WHSC1L1.

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity

Purified by peptide immunoaffinity chromatography.

Specificity

Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Angrand, P.O., et al., Genomics 74(1):79-88 (2001).|Stec, I., et al., FEBS Lett. 473(1):1-5 (2000).|Stec, I., et al., Genomics 76 (1-3), 5-8 (2001) (): ().

USBio References

No references available

Technical Data

043874

Clone Type

Host

Source

Isotype

Grade

Applications

Crossreactivity

Gene ID

Gene #

Shipping Temp

Storage Temp

Rabbit Anti-WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, WHSC1-like protein 1, Wolf-Hirschhorn syndrome candidate 1-like protein 1, Whistle, NSD3, DC28)

Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, WHSC1-like protein 1, Wolf-Hirschhorn syndrome candidate 1-like protein 1, Whistle, NSD3, DC28

References

USBio References