Technical Data

043898
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_064520.2
Gene ID
56897
Gene #
WRNIP1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-WRNIP1, NT (WRNIP1, WHIP, ATPase WRNIP1, Werner helicase-interacting protein 1)
WRNIP1, WHIP, ATPase WRNIP1, Werner helicase-interacting protein 1

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
WRNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human WRNIP1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Kaur, S., et al. Cell Cycle 9(15):3106-3111(2010)|Yoshimura, A., et al. Genes Genet. Syst. 84(2):171-178(2009)|Crosetto, N., et al. J. Biol. Chem. 283(50):35173-35185(2008)|Mano, Y., et al. Cancer Sci. 98(12):1902-1913(2007)|Bish, R.A., et al. J. Biol. Chem. 282(32):23184-23193(2007)
USBio References
No references available
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