Technical Data

043918
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_066569.1
Gene ID
7504
Gene #
XK
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-XK, NT (XK, XKR1, XRG1, Membrane transport protein XK, Kell complex 37kD component, Kx antigen, XK-related protein 1)
XK, XKR1, XRG1, Membrane transport protein XK, Kell complex 37kD component, Kx antigen, XK-related protein 1

This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 83-111 in the N-terminal region of human XK. Species Sequence Homology: mouse and rat.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human XK.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Miranda, M., et al. Mov. Disord. 22(9):1358-1361(2007) 2. Claperon, A., et al. Brain Res. 1147, 12-24 (2007) : 3. Walker, R.H., et al. Transfusion 47(2):299-305(2007) 4. Olsen, J.V., et al. Cell 127(3):635-648(2006) 5. Jung, H.H., et al. Transfusion 43(7):928-938(2003)
USBio References
No references available
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