Technical Data

044578
Clone Type
Monoclonal
Host
Rat
Source
Human
Isotype
IgG2b
Clone Number
2.81
Grade
Highly Purified
Applications
E IP
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rat Anti-BAFF (BLyS, TALL-1, CD257, B Cell Activating Factor, TNFSF13B)
BLyS, TALL-1, CD257, B Cell Activating Factor, TNFSF13B

BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren's syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Applications
Suitable for use in ELISA and Immunoprecipitation. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
HA-tagged human BAFF.
Form
Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol.
Purity
>95% (SDS-PAGE)
Specificity
Recognizes human BAFF.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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