Mouse Anti-IL-1R2, blocking (Recombinant) (CD121 Antigen-like Family Member B, IL-1 Type II Receptor, Interleukin-1 Receptor beta, Interleukin-1 Receptor Type II, CD121b)
CD121 Antigen-like Family Member B, IL-1 Type II Receptor, Interleukin-1 Receptor beta, Interleukin-1 Receptor Type II, CD121b
The inflammatory actions of IL-1alpha and beta depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
Applications
Suitable for use in ELISA, Flow Cytometry and Neutralization. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant mouse IL-1R2 (extracellular domain).
Form
Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol
Purity
Purified by Protein A affinity chromatography from HEK293 cell culture supernatant.
Specificity
Recognizes mouse IL-1R2.
