125417
Clone Type
PolyclonalHost
MouseSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
WBCrossreactivity
HuAccession #
NM_001898.2, NP_001889.2Shipping Temp
Blue IceStorage Temp
-20°CMouse Anti-CST1 (Cystatin-SN, Cystain-SA-I, Cystatin-1, Salivary Cystatin-SA-1)
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
AA Sequence
MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full length human CST1, aa1-141 (NP_001889.2).
Form
Supplied as a liquid in PBS, pH 7.2.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CST1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Upregulation of the cysteine protease inhibitor, Cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer. Choi EH, Kim JT, Kim JH, Kim SY, Song EY, Kim JW, Kim SY, Yeom YI, Kim IH, Lee HG.Clin Chim Acta. 2009 Aug;406(1-2):45-51. Epub 2009 May 19.USBio References
No references available