Rabbit Anti-PVRL1 (CD111, Poliovirus Receptor-related Protein 1, Herpes Virus Entry Mediator C, Herpes virus Entry Mediator C, HveC, Herpes virus Ig-like Receptor, HIgR, Nectin-1, HVEC, PRR1) (Not for Export EU)
Nectin-1, also known as CD111 antigen, Poliovirus receptor-related protein 1(PRR-1) and Herpes virus entry mediator C (HVEC), is a 110kD type I transmembrane glycoprotein. Two additional splice forms (another type I transmembrane protein and a secreted protein) also exist. All three isoforms share the aa residues from (aa31-334). Nectin-1 is widely expressed in numerous tissues. It is a Ca2+-independent cell adhesion molecule that is a member of the Ig superfamily. The aa sequence of the human Nectin-1 extracellular domain is 93% and 96% identical to that of mouse and porcine Nectin-1, respectively.
Applications
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
AA Sequence
MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITAFCQLIYPGKGRTRARMF
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full length human PVRL1, aa1-352 (NP_976031.1).
Form
Supplied as a liquid.
Specificity
Recognizes human PVRL1.
