Somatostatin (also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G-protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Somatostatin inhibits a variety of physiological functions in the gastrointestinal tract, such as gastrointestinal motility, gastric acid production, pancreatic enzyme secretion, bile secretion and colonic fluid secretion. It also inhibits the secretion of pancreatic and intestinal hormones such as insulin, glucagon, secretin and vasoactive intestinal polypeptide (VIP).
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:1000-1:2000 (in PBS/0.3% Triton X-100 using Cy3 technique) 1:4000-1:8000 (in PBS/0.3% Triton X-100 using Bn/Av-HRP technique) Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic somatostatin conjugated to KLH with carbodiimide linker.
Form
Supplied as a lyophilized powder, 0.09% sodium azide. Reconstitute with 100ul distilled or deionized dH2O.
Specificity
Recognizes Somatostatin. Species Crossreactivity: rat, mouse, human, xenopus and zebrafish.
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