144534
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
WBCrossreactivity
Hu Mo RtGene ID
FGF22Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-Fibroblast growth factor 22 (FGF-22)
FGF22, Fibroblast growth factor 22, is a protein which in humans is encoded by the FGF22 gene. The FGF22 sequence in a genomic clone is assigned to 19p13.3. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. In situ hybridization demonstrated expression in the inner root sheath of the hair follicle. FGF22 is involved in hair development.
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human FGF22, different from the related mouse and rat sequence by one amino acid.
Form
Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human, mouse and rat FGF22. No crossreactivity with other proteins.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Nakatake, Y., Hoshikawa, M., Asaki, T., Kassai, Y., Itoh, N.Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle.Biochim. Biophys. Acta 1517: 460-463, 2001.|2. Terauchi, A., Johnson-Venkatesh, E. M., Toth, A. B., Javed, D., Sutton, M. A., Umemori, H.Distinct FGFs promote differentiation of excitatory and inhibitory synapses.Nature 465: 783-787, 2010.|3. Umemori, H., Linhoff, M. W., Ornitz, D. M., Sanes, J. R. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.Cell 118: 257-270, 2004.|USBio References
No references available