145392

Mouse Anti-Attractin (ATRN, DPPT-L, Mahogany Protein, MGCA)

Attractin (ATRN), also known as DPPT­L, is an ~200kD transmembrane glycoprotein that shows dipeptidyl peptidase activity similar to DPPIV/CD26. Attractin is involved in a variety of processes including monocyte­T cell adhesion, axon myelination, melanocyte pigment synthesis, and energy homeostasis. The extracellular region of human Attractin contains one EGF­like domain, one CUB domain, six Kelch repeats, four PSI domains, one C­type lectin domain, and two laminin EGF­like domains. Alternate splicing of human Attractin generates a secreted isoform that lacks the transmembrane and cyotplasmic regions. Attractin is transiently upregulated during T cell activation before expression switches to the 175kD secreted isoform which is released into the circulation. Soluble Attractin is preferentially expressed by leukocytes and differentiating neurons. It blocks neurite formation and is elevated in the CSF of astrocytoma patients. Within aa84­1272, human Attractin shares 95% aa sequence identity with mouse and rat Attractin.