Rabbit Anti-TLR8 (CD 288, CD288, CD288 antigen, TLR 8, Toll Like Receptor 8)
CD 288, CD288, CD288 antigen, TLR 8, Toll Like Receptor 8
TLR8 (Toll Like Receptor 8). Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses . These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.
Applications
Suitable for use in ELISA, Immunohistochemistry, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilutions
Western Blot: 0.5-2ug/ml Immunocytochemistry: 1:500 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to an internal region of human TLR8.
Form
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TLR8. Species Crossreactivity: mouse.
