Rabbit Anti-ADRA1B (ADRA1B, Alpha 1b, Alpha-1B Adrenergic Receptor, Alpha-1b-Adrenergic, Alpha-1B-Adrenergic Receptor, Alpha1b, Adrenoceptor alpha 1B, Alpha-1B AdrenoReceptor, Alpha1B-AR, Alpha1beta-AR, ALPHA1BAR, ADRA1, Alpha-1B Adrenoceptor, Alpha1b-Adrenergic)
The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation.
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (Formalin fixed paraffin embedded): 11ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 20aa from the C-terminus of human ADRA1B.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ADRA1B. Species crossreactivity: monkey, gorilla, mouse, rat, bovine, canine, hamster
