Rabbit Anti-F2RL3 (F2RL3, PAR4, Thrombin Receptor-like 3, Par-4, Protease-activated Receptor-4)
Proteinase-Activated Receptor 4 (PAR4) is a member of the Proteinase-Activated Receptor subfamily. Along with other protease-activated receptors, PAR4 mediates the effects of the enzyme, thrombin which include activation of platelets, leukocytes, endothelial cells, and mesenchymal cells at sites of vascular injury. These cellular responses are triggered through proteolytic activation of the receptors by thrombin.
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (Formalin fixed paraffin embedded): 5-10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 17aa from 2nd cytoplasmic domain of human F2RL3/PAR4. Species sequence homology: gorilla and monkey.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human F2RL3/PAR4. Species Crossreactivity: gibbon.
