Rabbit Anti-ROR Beta (Hinge Domain) (RORB, BA133M9.1, Nuclear Receptor ROR-beta, NR1F2, ROR Beta, ROR-BETA, Rorbeta, RZR-BETA, Nuclear Receptor RZR-beta, RAR-related Orphan Receptor B, RZRB)
Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer.
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 18aa from human RORB. Species sequence homology: xenopus.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ROR Beta. Species crossreactivity: bat, gibbon, bovine, chicken, canine, gorilla, hamster, equine, monkey, mouse, rabbit, rat and sheep.
