Goat Anti-SRCAP (aa309-322) (Domino homolog 1, Domino homolog 2, DOMO1, EAF1, FLJ44499, Helicase SRCAP, KIAA0309, OTTHUMP00000208671, Snf2-related CBP activator protein, Snf2-related CREBBP activator protein, Swi2/Snf2-related ATPase homolog, Domino homolog 1, SWR1)
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Applications
Suitable for use in Peptide ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Peptide ELISA: 1:128,000 Immunohistochemistry: 5-10ug/ml using paraffin embedded human skin as sample. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Peptide with sequence C-QEGNDAEAQRREIE, from the internal region of the protein sequence according to NP_006653.2. Species sequence homology: mouse, rat, canine and porcine
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SRCAP.
