Technical Data

213566
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo Rt
Gene ID
8406
Gene #
SRPX
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SRPX (Sushi Repeat-containing Protein SRPX, DRS, ETX1, SRPX1)

X-linked retinitis pigmentosa (XLRP) is a retinal degeneration disorder. The most common form of XLRP has been localized to the gene locus RP3 by linkage and deletion analysis. RP3 maps to chromosome Xp21.1 between CYBB and OTC. The sushi-repeat-containing protein, x chromosome (SRPX) gene, also designated ETX1, resides within this region and is deleted in XLRP patients. There are at least two splice variants of SRPX, one of which contains a thirty amino acid signal peptide. Both variants contain three complement control protein domains, a hydrophobic region for membrane anchorage, and a cytoplasmic carboxy terminus. SRPX is expressed in retina and heart. SRPX is highly homologous to the drs (downregulated by v-src) human homolog, which suggests a role for SRPX as a tumor suppressor.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to human SRPX.
Form
Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Purity
Purified by affinity chromatography.
Specificity
Recognizes SRPX. Species Crossreactivity: human, mouse, rat

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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