Chicken Anti-Presenilin 1 (PS-1, Protein S182, PS1-CTF12, PSEN1, AD3, PS1, PSNL1)
Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000-1:4000 Western Blot: 1:1000-1:4000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mixture of two human Presenilin 1 peptides aa311-322 and aa341-352. Both sequences are highly conserved in human, mouse and rat.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity
Recognizes human Presenilin 1. Species Crossreactivity: Mouse, rat
