Technical Data

217237-Biotin
Clone Type
Monoclonal
Host
Mouse
Source
Rabbit
Conjugate
Biotin
Isotype
IgG2b,k
Clone Number
L57/46
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo Rb Rt
Accession #
NP_001129994
Shipping Temp
Blue Ice
Storage Temp
-20°C
Notes
Preservative Free
BSA Free
Mouse Anti-CACNA1C (Voltage-dependent L-type Calcium Channel Subunit alpha-1C, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 1, Cardiac Muscle, Voltage-gated Calcium Channel Subunit alpha Cav1.2, CACH2, CACN2, CACNL1A1, CCHL1A1) (Biotin)

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Recombinant protein corresponding to rabbit Cav1.2 calcium channel at the cytoplasmic domain near the C-terminus.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes rabbit Cav1.2 calcium channel at the cytoplasmic domain. Species Crossreactivity: human, mouse and rat.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net