Rabbit Anti-LPAR5 (Lysophosphatidic Acid Receptor 5, LPA Receptor 5, LPA-5, G-protein Coupled Receptor 92, G-protein Coupled Receptor 93, GPR92, GPR93) (APC)
Lysophosphatidic acid receptor 5 (LPA receptor 5), also known as GPR92, is a G12/13 and Gq coupled receptor that mediates the signaling of LPA. Ligand binding to LPA receptor 5 may increase intracellular levels of cAMP and calcium, resulting in the activation of a wide range of effector molecules. Recent studies have demonstrated that LPA receptor 5 is abundantly expressed in human mast cells, and mediates the release of the macrophage inflammatory protein-1b (MIP-1b), indicating that LPA receptor 5 may play a role in innate and adaptive immunity.
Applications
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution
Immunocytochemistry: 1:500 Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Linear peptide corresponding to the extracellular domain of human LPA receptor 5, conjugated to KLH.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes the extracellular domain of human LPA receptor 5. Species Crossreactivity: mouse.
