REG3A, also known as Regenerating islet-derived protein 3 alpha, Reg III-alpha, and pancreatitis associated protein, is a 174aa containing stress protein involved in the control of bacterial proliferation. This secreted protein is generally found in the apical region of pancreatic acinar cells and appears in pancreatic juice after induction of pancreatic inflammation. It has a possible role in inducing new pancreatic islets development. REG3A belongs to the Reg-related family with a C-type lectin domain and is constitutively expressed in intestine while low expression is found in healthy pancreas. Overexpression of REG3A is seen during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.