Rabbit Anti-FNIP1 (KIAA1961, FLCN-Interacting Protein, FNIP1, Folliculin Interacting Protein 1) (Not for Export EU)
Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD (FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway
Applications
Suitable for use in Western Blot, Immunoprecipitation. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000-1:2000. Predicted molecular weight: 131kD. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
A peptide at the N-terminus of FNIP1, MAPTLFQKLFSKRTGLGAC-amide
Form
Supplied as a liquid in 0.09% sodium azide.
Specificity
Recognizes FNIP1. Species Crossreactivity: Mouse, Human
