Rabbit Anti-SUN1 (Protein unc-84 Homolog A, Sad1/unc 84 Protein like 1, Sad1/unc-84 Protein-like 1, Sun Domain-containing Protein 1, Sun1, SUN1_HUMAN, UNC 84 Homolog A (C elegans), UNC 84A, UNC84 A, UNC84NC84 Homolog A (C elegans)) (Not for Export EU)
Protein unc-84 homolog A, Sad1/unc 84 protein like 1, Sad1/unc-84 protein-like 1, Sun domain-containing protein 1, Sun1, SUN1_HUMAN, UNC 84 homolog A (C elegans), UNC 84A, UNC84 A, UNC84NC84 homolog A (C elegans)
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs).
Applications
Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunocytochemistry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GST-Sun 1 peptide
Form
Supplied as a liquid in 0.09% sodium azide.
Specificity
Recognizes SUN1. Species Crossreactivity: Human
