Technical Data

302733
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
WB
Crossreactivity
Hu
Gene ID
6330
Gene #
SCN4B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SCN4B (Sodium Channel Subunit beta-4, SCN4B)

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to human SCN4B.
Form
Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity
Purified
Specificity
Recognizes human SCN4B. Species Crossreactivity: human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Yu F.H.,et al.J. Neurosci. 23:7577-7585(2003).|Taylor T.D.,et al.Nature 440:497-500(2006).|Gilchrist J.,et al.Proc. Natl. Acad. Sci. U.S.A. 110:E5016-E5024(2013).|Medeiros-Domingo A.,et al.Circulation 116:134-142(2007).|Olesen M.S.,et al.Cardiovasc. Res. 89:786-793(2011).|
USBio References
No references available
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