303196

Rabbit Anti-CD10 (Atriopeptidase, CALLA, CD10 Antigen, Common Acute Lymphocytic Leukemia Antigen, Enkephalinase, EPN, Gp100, Membrane Metallo Endopeptidase (Neutral Endopeptidase, Enkephalinase), Membrane Metallo Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10), Membrane Metallo Endopeptidase, Membrane Metallo Endopeptidase Variant 1, Membrane Metallo Endopeptidase Variant 2, Membrane Metalloendopeptidase, Membrane Metalloendopeptidase Neutral Endopeptidase Enkephalinase, Membrane Metalloendopeptidase Neutral Endopeptidase Enkephalinase CALLA CD10, Membrane Metalloendopeptidase Variant 1, Membrane Metalloendopeptidase Variant 2, MME, NEP, NEP_HUMAN, Neprilysin, Neutral Endopeptidase 24.11, Neutral Endopeptidase, SFE, Skin Fibroblast Elastase)

CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, or common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.