Rabbit Anti-Dual specificity Protein phosphatase 26 (DUSP26)
Dual specificity phosphatase SKRP3,Low-molecular-mass dual-specificity phosphatase 4,DSP-4,LDP-4,Mitogen-activated protein kinase phosphatase 8,MAP kinase phosphatase 8,MKP-8,Novel amplified gene in thyroid anaplastic cancer,DUSP26,DUSP24, LDP4, MKP8, NATA1,SKRP3
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant human Dual specificity protein phosphatase 26 protein (aa1-211).
Form
Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Purity
Purified by Protein G affinity chromatography.
Specificity
Species Crossreactivity: mouse
