Rabbit Anti-NPPB (BNP 32, Brain natriuretic peptide 32, Brain Type natriuretic peptide, Gamma brain natriuretic peptide, Natriuretic peptide B, Natriuretic peptide brain Type, Natriuretic peptide Precursor B, Natriuretic peptides B, NPPB, NPPB Protein)
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
Applications
Suitable for use in ELISA, Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:1000-1:10,000 Immunohistochemistry: 1:40-1:150 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide of human NPPB
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human NPPB.
