Rabbit Anti-UHRF2 (E3 Ubiquitin-Protein Ligase UHRF2, Np95/ICBP90-like RING Finger Protein, Np95-like RING Finger Protein, Nuclear Protein 97, Nuclear zinc Finger Protein Np97, RING Finger Protein 107, UHRF2, NIRF, RNF107)
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
Applications
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:2000-1:5000 Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide of human UHRF2
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human UHRF2. Species Crossreactivity: mouse
