Rabbit Anti-VSIG2 (CTXL, V-set and Immunoglobulin Domain-containing Protein 2, Cortical Thymocyte-like Protein, CT-like Protein, CTH, UNQ2770/PRO7154)
V-set and immunoglobulin domain-containing protein 2,Cortical thymocyte-like protein,CT-like protein,VSIG2,CTH,CTXL
CTXL, a cortical thymocyte marker, is a member of the immunoglobulin (Ig) superfamily and has features of both antigen specific receptors and adhesion molecules. This single pass, type I protein contains a signal peptide, an extracellular V type Ig like domain followed by a C2 type Ig like domain and a cytoplasmic tail. Expression levels of CTXL are high in the stomach, colon, prostate, trachea, and thyroid gland, with lower levels observed in bladder and lung tissues. CTXL is not expressed in the thymus. CTXL is developmentally regulated and may be involved in thymocyte selection. It localizes to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion and transmigration of leukocytes.
Applications
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant human V-set and immunoglobulin domain-containing protein 2 protein (aa24-243).
Form
Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human VSIG2.
