Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
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