Technical Data

352486
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_543140
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-RLN3 (Relaxin-3, RXN3, H3, ZINS4, INSL7)

Relaxin-3 (RLN3) is a member of Relaxin family, a group of endocrine and autocrine/paracrine hormones that belong to the insulin gene superfamily (1,2). RLN3 can bind to and activate three relaxin-family peptide receptors: RXFP1, RXFP3, and RXFP4 (3). In contrast to the widespread expression of the related proteins RLN1 and RLN2, RLN3 is predominantly expressed in brain and to a lesser extent in the thymus, kidney and spleen (1). RLN3 has been suggested to play a role in feeding, metabolism, stress, arousal, learning, and memory (4).

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Human Brain Tissue Lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Peptide corresponding to 19aa near the center of human RLN3.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human RLN3.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Bathgate RA, Samuel CS, Burazin TC, et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J. Biol. Chem. 2002; 277:1148-57. |2. Wilkinson TN and Bathgate RA. The evolution of the relaxin peptide family and their receptors. Adv. Exp. Med. Biol. 2007; 612:1-13. 3. Silvertown JD, Neschadim A, Liu HN, et al. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. Regul. Pept. 2010; 159:44-53.
USBio References
No references available
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