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368308 Mouse Anti-PTK2B (Protein-Tyrosine Kinase 2-beta, Calcium-Dependent Tyrosine Kinase, CADTK, CAKB, FADK2, FAK2, FRNK, PKB, PTK, PYK2, RAFTK)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q14289
Isotype
IgG2a,k
Clone Number
3G14
Grade
Ascites
Applications
E WB
Crossreactivity
Hu
Accession #
AAH36651, BC036651
Gene ID
2185
Gene #
PTK2B
Shipping Temp
Blue Ice
Storage Temp
-20°C

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Applications
Suitable for use in ELISA, Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
AA Sequence
VYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTA
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PTK2B (AAH36651, aa682-871) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Form
Supplied as a liquid.
Purity
Ascites
Specificity
Recognizes human PTK2B.
Conjugates
Pricing
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