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377998 Mouse Anti-UGDH (UDP-glucose 6-dehydrogenase, UDP-Glc Dehydrogenase, UDPGDH, UDP-GlcDH)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
O60701
Isotype
IgG2b,k
Clone Number
AT2G11
Grade
Affinity Purified
Applications
E FC IC WB
Crossreactivity
Hu
Accession #
NP_003350
Shipping Temp
Blue Ice
Storage Temp
-20°C

UGDH is a member of the UDP-glucose, GDP-mannose dehydrogenase family and is a ubiquitously expressed protein most abundant in the liver. This protein converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis.

Applications
Suitable for use in Immunocytochemistry/Immunofluorescence, Flow Cytometry, ELISA, Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Hybridoma
F0 myeloma cells with spleen cells from BALB/c mice.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to aa1-494 from human UGDH expressed in E. coli.
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human UGDH.
References
1. Bontemps Y., et al. (2003) J Biol Chem. 278(24): 21566-75.|2. Vatsyayan J., et al. (2006) Biosci Biotechnol Biochem. 70(2): 401-10.|3. Egger S., et al. (2011) J Biol Chem. 286(27): 23877-87.
USBio References
No references available
Conjugates
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