Rabbit Anti-RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4, Exchange Factor Directly Activated by cAMP 2, Exchange Protein Directly Activated by cAMP 2, EPAC 2, cAMP-regulated Guanine Nucleotide Exchange Factor II, cAMP-GEFII, RAPGEF4, CGEF2, EPAC2)
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Applications
Suitable for use in ELISA, Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to aa1-210 of human RAPGEF4.
Form
Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human RAPGEF4.
