407040

Rabbit Anti-RNF5 (E3 Ubiquitin-protein Ligase RNF5, Protein G16,RING Finger Protein 5, Ram1 Homolog, HsRma1, RNF5, G16, NG2, RMA1)

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the \'Lys-63\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the \'Lys-48\'-linked polyubiquitination of TMEM173 at \'Lys-150\' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.