Deoxyribonuclease-1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI
Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).
Applications
Suitable for use in ELISA, Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within aa87-121 of the Central region of human DNASE1.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human DNASE1. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Shak S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:9188-9192(1990).|2. Yasuda T.,et al.Ann. Hum. Genet. 59:1-15(1995).|3. Oliveri M.,et al.Eur. J. Immunol. 31:743-751(2001).|4. Kominato Y.,et al.FEBS J. 273:3094-3105(2006).|5. Martin J.,et al.Nature 432:988-994(2004).
USBio References
No references available
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