Anhidrotic ectodysplasin receptor 1, DL, Downless (mouse) homolog, Downless homolog, Downless mouse homolog of, ECTD10A, ECTD10B, Ectodermal dysplasia receptor, Ectodysplasin 1 anhidrotic receptor, Ectodysplasin A receptor, Ectodysplasin A1 isoform receptor, Ectodysplasin-A receptor, ED 1R, ED 3, ED 5, ED1R, ED3, ED5, EDA 1R, EDA 3, EDA A1 receptor, EDA A1R, EDA-A1 receptor, EDA1R, EDA3, Edar, EDAR_HUMAN, HRM1, Tumor necrosis factor receptor superfamily member EDAR
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Applications
Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000-1:3000, incubate membrane with diluted antibody in TBS, 5% milk, 0.1% Tween20 at 4°C with gentle shaking, overnight. ELISA (peptide): 1:20,000-1:40,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to human EDA-A1 Receptor. Species sequence homology: porcine (88%), rabbit (100%), canine (88%)
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes endogenous levels of total human EDA-A1 Receptor. Species Crossreactivity: mouse
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