Technical Data

552743
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1
Clone Number
2F1B4G9
Grade
Purified
Applications
E FC WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-CD352
SLAMF6; KALI; NTBA; KALIb; Ly108; NTB-A; SF2000

The protein encoded by this gene is a type I transmembrane protein belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications
Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:10,000 Flow Cytometry: 1:200-1:400 Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Purified recombinant protein fragment corresponding to aa: extra22-226 from human CD363, expressed in E. coli.
Form
Supplied as a liquid in PBS, 0.05% sodium azide.
Purity
Purified
Specificity
Recognizes human CD352.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. J Immunol. 2014 May 1;192(9):4202-9. |2. J Biol Chem. 2012 Nov 2;287(45):38168-77.
USBio References
No references available
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