Rabbit Anti-ADAM 17, CT (A Disintegrin And Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)
ADAM-17, which is also known as CD156b, is expressed in a wide range of cells in culture. Its biological role is to convert the transmembrane trimeric form of TNF alpha to the soluble form. CD156 is also reported to process a number of other proteins, including L-selectin and TNF p75 receptor.
Applications
Suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:500 Optimal dilutions to be determined by researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Peptide corresponding to aa807-823 of human CD156b
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by affinity chromatography from whole serum.
Specificity
Recognizes the C-terminal region of the TNF alpha converting enzyme (TACE), designated CD156b at the 6th leukocyte typing workshop. TACE is a membrane-bound metalloprotease disintegrin which belongs to the mammalian ADAM family.
