Technical Data

A2275-61Q4
Clone Type
Polyclonal
Host
Mouse
Source
Human
Isotype
IgG
Grade
Purified
Applications
IF WB
Crossreactivity
Hu
Accession #
NP_663722.1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-APBB1 (Amyloid beta A4 Precursor Protein-binding Family B Member 1, Fe65 Protein, FE65, RIR)

APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.

Applications
Suitable for use in Western Blot and Immunofluorescence. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
APBB1 (NP_663722.1, 1-708aa) full-length human protein.
Form
Supplied as a liquid in PBS, pH 7.2.
Purity
Purified.
Specificity
Recognizes human APBB1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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