Rat Anti-Bcl 2 Modifying Factor (Bmf)
Bcl2 modifying factor, also known as BMF belongs to the Bcl2 protein family of apoptosis mediators. Bmf is constitutively expressed in many tissues. This protein contains a single Bcl2 homology domain 3 (BH3), and has been shown to bind Bcl2 proteins and function as an apoptotic activator. Also, BMF is a key molecule for histone deacetylase (HDAC) inhibitors which alters the balance between acetylation and deacetylation, significantly increasing histone acetylation, while strongly inducing apoptosis in a variety of cancer cell types.
Applications
Suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to mouse Bcl 2 Modifying Factor.
Form
Supplied as a liquid in PBS, 0.02% sodium azide
Purity
Purified by Protein G affinity chromatography
Specificity
Recognizes mouse Bcl 2 Modifying Factor. Species Crossreactivity: human
