B2553-60-APC

Rabbit Anti-Bone Morphogenic Protein Receptor 1A (CD292, BMPR-1A, Bone Morphogenetic Protein Receptor Type IA, Serine Threonine Protein Kinase Receptor R5, SKR5, Activin Receptor-like Kinase 3, ALK-3, ACVRLK3) (APC)

Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily of cytokines that affect bone and cartilage formation1. Mature BMPs are 30-38kD proteins that assume a TGF beta-like cysteine knot configuration1. Most BMPs are homodimers, but bioactive natural heterodimers have also been reported1. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. They create an environment conducive for bone marrow development by stimulating the production of specific bone matrix proteins and altering stromal cell and osteoclast proliferation. BMPs also regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells, and are responsible for normal dorsal/ventral patterning. Two type I receptors have been characterized, BMPR-IA (also designated activin receptor-like kinase ALK-3, BRK-1 and SKR5), and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7)2-5. Type I receptors involved in BMP signaling can independently bind the various BMP family proteins in the absence of type II receptors. BMPR-IA and BMPR-IB are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion 2,6.