Technical Data

C2097-86B
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E
Crossreactivity
Hu
Accession #
NP_061496.2, NP_938192.1, NP_938194.1, NP_938198.1, NP_938199.1, NP_938200.1, NP_938407.1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Goat Anti-Cav3.1 (CACNA1G) (Calcium Channel, Voltage-Dependent, T Type, Alpha 1G Subunit, Cacna1g)
NBR13, MGC117234, Cav3.1, Ca(V)T.1, calcium channel, voltage-dependent, T type, alpha 1G subunit, CACNA1G

Voltage-activated calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. See MIM 601011. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.

Applications
Suitable for use in ELISA. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:32,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-AEEISKREDASGQLS, from the internal region of human Cav3.1 (NP_061496.2, NP_938192.1, NP_938194.1, NP_938198.1, NP_938199.1, NP_938200.1, NP_938407.1)
Form
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by peptide affinity chromatography.
Specificity
Recognizes Cav3.1. Species sequence homology: human, rat, canine, bovine. This antibody is expected to recognize isoform 1 (NP_061496.2), 4 (NP_938199.1), 5 (NP_938194.1), 8 (NP_938198.1), 9 (NP_938192.1), 10 (NP_938200.1) and isoform 15 (NP_938407.1).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL, Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci. 2009 Feb 11;29(6):1615-25.
USBio References
No references available
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