C2254-56F

Mouse Anti-CD3 (Early T Cell Marker, T Cell receptor Complex, TCR)

The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intracytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 is a highly specific marker for T cells and is present in majority of T cell neoplasms. CD3 antigen is expressed on ~60-80% of human peripheral blood lymphocytes, 20-40% of splenic lymphocytes, the majority of T-CLL and ~70% pf T-All.