Human CD50 is an adhesion molecule that interacts with LFA-1 (CD18/CD11a) and provides a costimulatory signal for T cells (1, 2, 3) which is thought to be essential for initiation of immune responses. Recognizes the D1 domain of the ICAM-3 molecule of 130kD (4), and blocks binding of CD11a (LFA-1) to CD50 (ICAM-3).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.