Mouse Anti-CD49d (Integrin alpha4, VLA4, LHR, Lymphocyte Homing Receptor)
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits.
Applications
Suitable for use in Immunohistochemistr, Immunocytochemistry, Immunoprecipitation, Flow Cytometry Analysis, ELISA and Radioimmunoassay. Other applications not tested.
Recommended Dilution
Immunohistochemistry: Acetone and alcohol fixatives. Optimal dilution determined by the researcher.
Biological Activity
Inhibits CS-1 and VCAM binding.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Human T lymphocytes
Form
Supplied as a liquid in PBS, pH 7.6, 0.01% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human and primate integrin alpha 4.
