C2436-12J
Clone Type
MonoclonalHost
MouseSource
HumanIsotype
IgG2a,kClone Number
CD84.1.21Grade
Affinity PurifiedApplications
FC IPCrossreactivity
HuShipping Temp
Blue IceStorage Temp
-20°CMouse Anti-CD84 (SLAM Family Member 5, Cell Surface Antigen MAX.3, Hly9-beta, Leukocyte Differentiation Antigen CD84, Signaling Lymphocytic Activation Molecule 5, SLAMF5)
CD84 is a 64-82 kD glycoprotein. It is a member of the SLAM (CD150) family, a CD2 subset of the Ig superfamily, also known as SLAMF5 or Ly9b. CD84 is expressed on B cells, monocytes, thymocytes, subset of (preferentially on CD45RO+) T cells, and platelets. CD84 functions as a homophilic adhesion molecule and enhances T cell activation and cytokine production. The antibody CD84.1.21 is able to enhance CD3 induced IFN-γ production and partially block CD84-Ig binding to lymphocytes.
Applications
Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
30019 cell line transfected with the CD84 full-length DNA
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CD84.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Martin, M., et al. 2001. J. Immunol. 167:3668. 2. Sayós, J., et al. 2001. Blood 97:3867. 3. Morra, M., et al. 2001. EMBO 20:5840. 4. Morra, M., 2001. J. Biol. Chem. 276:36809. 5. Romero, X., et al. 2004. Tissue Antigens 64:132. 6. de la Fuente, MA., et al. 1997. Blood 90(6):2398. 7. Tangye, SG., et al. 2002. Eur. J. Immunol. 32(6):1640. 8. Tangye, SG., et al. 2003. J. Immunol. 171:2485. 9. Martin, M., et al. 2001. J. Immunol. 167:3668.USBio References
No references available